Now, can the Jaguars (0-5 SU, 0-5 ATS), 27.5-point underdogs against the Broncos (5-0 SU, 3-2 ATS), pull off the biggest regular-season upset by a winless team in NFL history?

Let's start with covering the spread, obviously an easier task for Jacksonville than winning outright. Since 2003, underdogs of 14 points or more are 43-36-3 against the spread. Dating back to 1976, this is the ninth time a team has been favored by 20 or more points in a regular-season game, and the dog is 7-1 against the spread in those spots (via Sporting Charts).

The Pittsburgh Steelers are the only team to cover a spread of more than 20 points. In ‘76, Pittsburgh (9-3), a 27-point favorite against Tampa Bay (0-12), covered in a 42-0 blowout. That's what many bettors are envisioning Sunday, but, from an historical perspective, it makes more sense to take Jacksonville and the points.

Now, for the 30-to-1 question: Can the Jaguars pull off the upset and win outright? Bettors who take Jacksonville on the money line (+3,000) likely won't be rewarded.

In those games with 20-plus point spreads, the underdog is 0-8 straight up. In fact, favorites in games with a spread of 14 or more are 78-4 straight up since 2003 – three of those winners were +14, the other was +14.5.

But, hey, who are we to question anyone taking a shot on any team at 30-to-1?

There is a precedent, after all, for shocking upsets by winless teams, and the best example indirectly involves Denver quarterback Peyton Manning.

In 1997, Green Bay (8-2) was a 12.5-point favorite heading into a matchup at Indianapolis (0-9). The Packers, led by Brett Favre and Reggie White, were the defending Super Bowl champions. The Colts had Paul Justin starting for an injured Jim Harbaugh at quarterback.

Green Bay jumped out to a 14-3 lead, but the Colts scored two defensive touchdowns and trailed just 28-27 at halftime. The teams played a wild second half before Cary Blanchard's field goal as time expired gave Indianapolis a 41-38 win.

Indianapolis finished 1-15 that season and drafted Manning with the No. 1 pick in the 1998 NFL Draft. The Packers went on to lose Super Bowl XXXI to Denver, despite being 11-point favorites.

Been here, done that

Jacksonville, notably, has done it before against Denver. As 14-point underdogs in the 1996 divisional playoffs, the Jags beat the Broncos outright, 30-27.

Perhaps John Elway has mentioned that to Manning this week.